Human Gut Transport and Allostery – University of Copenhagen

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Human Gut Transport and allestery

The research group concentrates on two main research areas Human Gut Transport and Allostery.

Human Gut Transport

The aim of the research in the field of Human Gut Transport is to characterize especially functional receptor subtypes for serotonin and prostaglandins in human duodenum and colon. Read more about the research on Human Gut Transport

Allostery - synagics

The focus of the research is to develop tools to analyze dose-response effects at equilibrium in pharmaco-dynamics and combinatorial drug therapy. Read more about the research on allostery

Drug-Acceptor Interactions

Head of the lab Niels Bindslev have written a book entitled Drug-Acceptor Interactions. It is an extensive text on novel approaches to better understand experimental dose-response relations at equilibrium (synagics) in physical terms using cubic reaction schemes. The schemes are Hall’s (2000) allosteric two-state model (ATSM) and Bindslev’s (2004) homotropic two-state model (HOTSM).

A combined scheme of ATSM and HOTSM is the four-pane two-state model (FP-TSM). FP-TSM is the simplest model for interactions of an alloster, an orthoster and a receptor, involving 17 indenpendent parameters.  

The Book is available in a printed version at Co-action publishing.