Biophotonics and Biosimulation – University of Copenhagen

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Biophotonics and Biosimulation

We combine innovative experimental techniques, new methods of data analysis and  mechanism-based modeling to bring new insights into functional interactions between the key components of cells, tissues and organs, as well as how these interactions change in diseases.

With this we

  • develop an  in vivo experimental approach based on Raman spectroscopic tools to study hemoglobin/cytochrome properties and signaling pathways in living erythrocytes, cardiomyocytes, isolated heart and brain slices;
  • use the laser speckle flowmetry and advanced data analysis to evaluate coherent  behavior of  vascular networks in the kidney, retina and brain;
  • develop mechanism-based models and employ the concept of synchronization  to validate global dynamics of biological networks.

Experimental biophysics

Our experience covers application of different types of microscopies and spectroscopies to live cell studies and development of novel methods of data-analysis of multi-scale biological data:

  • the first application of laser interference microscopy to non-invasive live cell imaging and time-resolved study of cellular dynamics with combination of a newly developed multi-mode mathematical analysis;
  • the first investigation of erythrocytes properties and hemoglobin characteristics under the influence of cardiovascular diseases by means of Raman spectroscopy;
  • the first study of redox state of cytochromes c, c1 and b of complexes II and III in mitochondria of live cardiomyocytes, isolated heart and brain slices by means of Raman spectroscopy;
  • the first application of lase speckle flowmetry to study synchronization in the kidney and retinal vascular network.

Modeling and data analysis

Our experience in this field ranges from formal studies of coupled biological oscillators to mechanism-based modeling:

  • the first investigation of synchronization phenomena in multimode systems with application to nephron dynamics and pancreatic beta-cell activity;
  • the first functional model of neuron-glia interaction;
  • modeling studies of the spatial dynamics of a nephro-vascular network;
  • development of open source software based on wavelet technique.

We have published a monograph and have made contributions to a few books.

Research projects