We combine innovative experimental techniques, new methods of data analysis and mechanism-based modeling to bring new insights into functional interactions between the key components of cells, tissues and organs, as well as how these interactions change in diseases. With this,
- we develop an in vivo experimental approach based on Raman spectroscopic tools to study hemoglobin/cytochrome properties and signaling pathways in living erythrocytes, cardiomyocytes, isolated heart and brain slices;
- we use the laser speckle flowmetry and advanced data analysis to evaluate coherent behavior of vascular networks in the kidney, retina and brain;
- we develop mechanism-based models and employ the concept of synchronization to validate global dynamics of biological networks.