Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects
Research output: Contribution to journal › Journal article › Research › peer-review
The insulinotropic effect of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) is impaired in patients with type 2 diabetes. It remains unclear whether this impairment is a primary pathophysiological trait or a consequence of developing diabetes. Therefore, we aimed to investigate the insulinotropic effect of GIP and GLP-1 compared with placebo before and after 12 d of glucose homeostatic dysregulation in healthy subjects.
| Original language | English |
|---|---|
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 97 |
| Issue number | 4 |
| Pages (from-to) | 1363-70 |
| Number of pages | 8 |
| ISSN | 0021-972X |
| DOIs | |
| Publication status | Published - 2012 |
- Adult, Blood Glucose, C-Peptide, Gastric Inhibitory Polypeptide, Glucagon, Glucagon-Like Peptide 1, Glucose Clamp Technique, Glucose Intolerance, Glucose Tolerance Test, Humans, Incretins, Infusions, Intravenous, Insulin, Insulin Resistance, Insulin-Secreting Cells, Kinetics, Male, Severity of Illness Index, Young Adult
Research areas
ID: 40379513